Lack of testicular seipin causes teratozoospermia syndrome in men
نویسندگان
چکیده
منابع مشابه
Lack of testicular seipin causes teratozoospermia syndrome in men.
Obesity impairs male fertility, providing evidence for a link between adipose tissue and reproductive function; however, potential consequences of adipose tissue paucity on fertility remain unknown. Lack of s.c. fat is a hallmark of Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), which is caused by mutations in BSCL2-encoding seipin. Mice with a targeted deletion of murine seipin mod...
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Background: This study was aimed to see the frequency of polyzoospermia and teratozoospermia, among men with history of infertility, presenting at National Institute of Health, Islamabad. Material and Methods: Seven hundred and ninety married men presenting with a complaint of infertility underwent their semen analysis. They were categorized on the basis of sperm count and morphology. The sperm...
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testicular cancer is one of the commonest cancers in men of working age, and is increasing in incidence in europe and north america. one suggested mechanism of causation is that there is impaired differentiation of germ cells in the pre- or perinatal period, followed by malignant transformation in later life, possibly by a hormonal mechanism. endocrine disrupting chemicals (edcs) have been a ma...
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Abstract Background: Single nucleotide polymorphisms (SNPs) in some genes which are involving in sperm maturation, are considered as one of the main reason for male infertility. Any changes in protamine genes may cause abnormal histone-protamine replacement during spermiogenesis and have been indicated to cause sperm DNA damage and infertility. Objective: The aim of present case-control study w...
متن کاملOccupational causes of testicular cancer in adults.
Testicular cancer is one of the commonest cancers in men of working age, and is increasing in incidence in Europe and North America. One suggested mechanism of causation is that there is impaired differentiation of germ cells in the pre- or perinatal period, followed by malignant transformation in later life, possibly by a hormonal mechanism. Endocrine disrupting chemicals (EDCs) have been a ma...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1324025111